Knowledge Update

​New York, June 1 (IANS) Researchers from Duke University have discovered a potential new class of small-molecule drugs that simultaneously block key targets in the treatment of pain.

The findings could lead to the development of a new drug to treat conditions including skin irritation and itching, headaches, jaw pain, and abdominal pain stemming from the pancreas and colon.

"We are very pleased with what is a first chapter in a highly promising story," said Wolfgang Liedtke, Professor at Duke University School of Medicine in Durham.

"We hope to be able to develop these compounds for clinical use in humans or animals," Liedtke noted.

In the new study, published in the journal Scientific Reports, the researchers initially aimed to develop more effective blockers of TRPV4, a molecule their previous research had shown transmits skin irritation elicited by sunburn, and painful sensations coming from the head and face. 

The researchers used a prototype TRPV4 blocker in a 2009 study and then set out to develop more potent versions.

Compared to the prototype, one of the new candidate drugs, called "16-8," worked 10 times more effectively in cells with active TRPV4 that are key for the development of osteoarthritis.

It also worked well in another cell type involved in nerve cell injury, stroke and epilepsy.

But to their surprise, when assessing the specificity of 16-8, the scientists discovered that it also blocked TRPA1, which is a promising target in pain and itch research.

"As a physician, I soon realised the enormous potential that these compounds might have, given how beneficial dual-target molecules can be in clinical medicine," Liedtke said.

In this study, the drug 16-8 also quelled pain in living animals, including abdominal aches in mice with pancreas inflammation. 

Liedtke sees potential for the 16-8 drug to treat osteoarthritis and other types of joint pain as well as head, face and jaw pain. 

In general, it might also treat aches radiating from internal organs or resulting from nerve cell injury, the study said.​

Sydney, May 25 (IANS) A team of Australian researchers has demonstrated an optics breakthrough that can revamp night vision by making infra-red technology easy-to-use and cheap.

The team reported a dramatic increase in the absorption efficiency of light in a layer of semiconductor that is only a few hundred atoms thick -- to almost 99 percent light absorption from the current inefficient 7.7 percent.

This can save millions of dollars in defence and other areas using sensing devices, and boost applications of technology to a host of new areas such as agriculture.

Infra-red devices are used for improved vision through fog and for night vision and for observations not possible with visible light.

High-quality detectors cost approximately $100,000 and some require cooling to -200 degrees Celsius.

The team discovered perfect thin film light absorbers could be created simply by etching grooves into them.

“Conventional absorbers add bulk and cost to the infrared detector as well as the need for continuous power to keep the temperature down. The ultra-thin absorbers can reduce these drawbacks," said professor Martijn de Sterke, co-author from University of Sydney's school of physics.

By etching thin grooves in the film, the light is directed sideways and almost all of it is absorbed, despite the small amount of material.

There are many applications that could greatly benefit from perfectly absorbing ultra-thin films, ranging from defence and autonomous farming robots to medical tools and consumer electronics. The findings are forthcoming in the journal Optica.​

New York, June 1 (IANS) Researchers from Duke University have discovered a potential new class of small-molecule drugs that simultaneously block key targets in the treatment of pain.

The findings could lead to the development of a new drug to treat conditions including skin irritation and itching, headaches, jaw pain, and abdominal pain stemming from the pancreas and colon.

"We are very pleased with what is a first chapter in a highly promising story," said Wolfgang Liedtke, Professor at Duke University School of Medicine in Durham.

"We hope to be able to develop these compounds for clinical use in humans or animals," Liedtke noted.

In the new study, published in the journal Scientific Reports, the researchers initially aimed to develop more effective blockers of TRPV4, a molecule their previous research had shown transmits skin irritation elicited by sunburn, and painful sensations coming from the head and face. 

The researchers used a prototype TRPV4 blocker in a 2009 study and then set out to develop more potent versions.

Compared to the prototype, one of the new candidate drugs, called "16-8," worked 10 times more effectively in cells with active TRPV4 that are key for the development of osteoarthritis.

It also worked well in another cell type involved in nerve cell injury, stroke and epilepsy.

But to their surprise, when assessing the specificity of 16-8, the scientists discovered that it also blocked TRPA1, which is a promising target in pain and itch research.

"As a physician, I soon realised the enormous potential that these compounds might have, given how beneficial dual-target molecules can be in clinical medicine," Liedtke said.

In this study, the drug 16-8 also quelled pain in living animals, including abdominal aches in mice with pancreas inflammation. 

Liedtke sees potential for the 16-8 drug to treat osteoarthritis and other types of joint pain as well as head, face and jaw pain. 

In general, it might also treat aches radiating from internal organs or resulting from nerve cell injury, the study said.​

New York, June 1 (IANS) The side effects of antipsychotics can be quite problematic and researchers have found that the proportion of adolescents with autism or intellectual disability has increased among youths treated with these medications.

Antipsychotics are a class of psychiatric medication primarily used to manage psychosis, including delusions, hallucinations, paranoia or disordered thought and principally for schizophrenia and bipolar disorders.

The researchers also found that the number of adolescents with autism spectrum disorder being prescribed antipsychotics has also increased over the years in the US. 

For the study, the team performed a meta-analysis of 39 studies and over 350,000 youths with mental illness were examined on the frequency and time trends of antipsychotic prescribing in youth with autism spectrum disorders or intellectual disability.

"The side effects of antipsychotics drugs can be quite problematic, especially in children and adolescents," said lead researcher Christoph Correll from Hofstra University in the US. 

The results were published in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP). 

Currently, second-generation antipsychotics are the only Food and Drug Administration-approved medications for youths with autism. However, these are approved only for the symptomatic control of irritability and aggression. 

Core symptoms of autism spectrum disorders (eg, social and communication difficulties) and core symptoms of intellectual disability, such as problems with understanding and responding appropriately to external data, did not appear to be affected by these medications. 

Clinicians need to consider using psychosocial interventions that are proven to be efficient for behavioural dysregulation such as irritability and aggression, before prescribing antipsychotics to adolescents with autism or intellectual disability, the researchers suggested.

When prescribing antipsychotics, it is imperative to regularly monitor both their efficacy and tolerability in patients through body weight, fasting lipids and glucose, extrapyramidal side effects, sedation, and sexual/reproductive adverse effects as well as to manage abnormalities appropriately, the researchers noted.​

​Toronto, June 1 (IANS) What is the mass of our Milky Way? It is 7X1011 solar masses or, in simpler terms, the mass of our Sun multiplied by 700 billion, say researchers who have tried to measure this galactic challenge with a new method.

The Sun, for the record, has a mass of two nonillion (that's two followed by 30 zeroes) kg or 330,000 times the mass of the Earth.

“And our galaxy isn't even the biggest galaxy," said Gwendolyn Eadie, PhD candidate in physics and astronomy at Hamilton-based McMaster University.

Measuring the mass of our home galaxy, or any galaxy, is particularly difficult. 

A galaxy includes not only stars, planets, moons, gases, dust and other objects and material, but also a big helping of dark matter, a mysterious and invisible form of matter that is not yet fully understood. 

Astronomers, however, can infer the presence of dark matter through its gravitational influence on visible objects.

Eadie has been studying the mass of the Milky Way and its dark matter component by using the velocities and positions of globular star clusters that orbit the Milky Way.

The orbits of globular clusters are determined by the galaxy's gravity, which is dictated by its massive dark matter component. 

What's new about Eadie's research is the technique she devised for using globular cluster (GCs) velocities.

The total velocity of a GC must be measured in two directions: one along our line-of-sight, and one across the plane of the sky (the proper motion). 

Eadie has developed a way to use these velocities that are only partially known, in addition to the velocities that are fully known, to estimate the mass of the galaxy. 

Her method also predicts the mass contained within any distance from the centre of the galaxy, with uncertainties, which makes her results easy to compare with other studies.

Eadie and her academic supervisor William Harris, professor of physics and astronomy at McMaster, have submitted their work for publication in the Astrophysical Journal.​

​Sydney, June 1 (IANS) Contrary to previous beliefs, the population size of a bee specie has increased dramatically during the global warming following the last Ice Age, finds a study.

The Australian small carpenter bee -- found in sub-tropical, coastal and desert areas in Australia -- has flourished in the period of global warming following the last Ice Age some 18,000 years ago.

"You see a rapid increase in population size from about 18,000 years ago just as the climate began warming up after the last Ice Age," says lead author Rebecca Dew from the Flinders University of South Australia. 

Previous studies have showed that bees -- major pollinators and critical for many plants, ecosystems, and agricultural crops -- from diverse habitats respond strongly to climate change.

"Different climate, different environment but the bees have responded in the same way at around the same time," Dew said in the paper published in the Journal of Hymenoptera Research.

For the study, the team modelled its past responses to climate change with the help of DNA sequences. 

"It is really interesting that you see very similar patterns in bees around the world," Dew noted. 

However, some studies showed that some rare and ancient tropical bees require cool climate and, as a result, are already restricted to the highest mountain peaks. For these species, climate warming could spell their eventual extinction.​

​London, June 1 (IANS) An international team of astrophysicists has stumbled upon an unusual astronomical object -- an Einstein ring which is a distorted image of a very distant galaxy termed as “the source”.

Doctoral student Margherita Bettinelli from the Instituto de Astrofísica de Canarias (IAC) and the University of La Laguna (ULL) along with the team discovered this rare phenomenon while analysing images of the Sculptor dwarf galaxy. 

The phenomena, predicted by Albert Einstein's theory of General Relativity, is quite rare but scientifically interesting. The interest is sufficiently strong that this object has been given its own name: "The Canarias Einstein ring". 

The chance discovery was made when Bettinelli was examining data taken through the “Dark Energy Camera” (DECam) of the 4m Blanco Telescope at the Cerro Tololo Observatory in Chile. 

She noticed the peculiar morphology of the Einstein ring. 

The “Canarias Einstein ring” is one of the most symmetrical discovered until now and is almost circular, showing that the two galaxies are almost perfectly aligned. 

The source galaxy is 10,000 million light years away from us. 

Due to the expansion of the Universe, this distance was smaller when its light started on its journey to us, and has taken 8,500 million years to reach us. 

“We observe it as it was then: a blue galaxy which is beginning to evolve, populated by young stars which are forming at a high rate. The lens galaxy is nearer to us, 6,000 million light years away, and is more evolved. Its stars have almost stopped forming, and its population is old,” the authors noted.

"Studying these phenomena gives us especially relevant information about the composition of the source galaxy, and also about the structure of the gravitational field and of the dark matter in the lens galaxy,” explained Antonio Aparicio, one of the astrophysicts who is leading the research. 

The results were published in the international journal Monthly Notices of the Royal Astronomical Society.​

​London, June 1 (IANS) The high-tech 3D mapping of our newly-found relative Homo naledi's home has opened the doors for scientists to use the space-age technology to search for pre-historic bones.

The extremely difficult conditions in which Professor Lee Berger's team from University of the Witwatersrand's (Wits) was forced to work gave rise to the use of space-age technology to map the Dinaledi chamber and Rising Star Cave in which over 1500 Homo naledi fossils were found.

Ashley Kruger, PhD candidate in palaeoanthropology, roped in the use of high-tech laser scanning, photogrammetry and 3D mapping technology to bring high-resolution digital images on an almost real-time basis in order to make vital decisions regarding the underground excavations.

“This is the first time ever where multiple digital data imaging collection has been used on such a sale, during a hominin excavation," Kruger said.

In 2013, after the discovery of the hominin assemblage, Berger planned an expedition to excavate what became known as the Dinaledi Chamber, a cave system near the Sterkfontein Caves, about 40 km north-west of Johannesburg in South Africa. 

An all-female team of six were selected to undertake the underground excavation due to the challenge of navigating a 12 meter vertical Chute, and passing through an 18 cm gap.

Berger himself was unable to go down into the chamber, which forced the team to introduce high-tech digital imaging techniques to virtually bring the exploration site to the surface.

Kruger and colleagues have now mapped the entire path of the Rising Star Cave, including the Dinaledi Chamber, both on the surface and underground.

“The 3D scans of the cave and excavation area helped scientists above ground immensely in making decisions about the next step to take with regards to excavations,” added Dr Marina Elliot, Rising Star excavation manager.

“These methods provided researchers with a digital representation of the site from landscape level right down to individual bones,” noted Kruger in a paper published in the scientific journal, the South African Journal of Science.

The precise digital reconstruction of the Rising Star Cave provides new insights into the Dinaledi Chamber's structure and location, as well as the exact location of the fossil site, the authors stated. ​

Toronto, June 1 (IANS) Cooling down the roofs by using reflective surfaces can not only help you beat the heat but also lower air-conditioning bills, suggests new research.

"Our study proves that cool roofs for commercial buildings are a net saver of energy in all climates that use air conditioning during the summer," said Hashem Akbari, Professor at Concordia University in Montreal, Canada and the study's senior author.

"In cooler climates, installing cool roofs may even prevent buying an air conditioner altogether. Even in non-air-conditioned buildings, cool roofs improve comfort during hot summer days. And in extreme cases, these roofs may even save lives by reducing the risk of heat stroke," Akbari noted.

The findings appeared in the journal Energy and Buildings.

"Our research shows that any improvement to a roof that limits the summertime solar heat gain actually results in energy-cost savings for the building owner, as well as a reduction in the building's overall environmental impact," Akbari said.

For the study, the researchers used modelling software to simulate energy consumption for several prototype office and retail buildings in four cold-climate cities in North America - Anchorage, Milwaukee, Montreal and Toronto.

They found that cool roofs for the simulated buildings resulted in annual energy expenditure savings in all municipalities.

The research also showed that cool roofs can reduce the peak electric demand of the buildings by up to five watts per square metre.

"On a large scale, cool roofs can moderate the air temperature surrounding a building, decrease greenhouse gas emissions and mitigate the urban heat island effect," Akbari said

"Put simply, cool roofs cool the globe," he noted.​